Celastrol is extracted from Tripterygium wilfordii.In low nanomolar concentrations celastrol was begin to abolish the assembly by animal monocytes and macrophages of the pro-inflammatory cytokines TNF-alpha and IL-1beta.
Celastrol aswell decreased the induced announcement of chic II MHC molecules by microglia. In macrophage birth beef and endothelial beef celastrol decreased induced but not basal NO production.
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